The Emergence and Impact of the M1UK Lineage on Invasive Group A Streptococcus Disease in Aotearoa New Zealand
journal contribution
posted on 2025-03-05, 04:43 authored by Anna VestyAnna Vesty, Xiaoyun Ren, Prachi Sharma, Natalie LorenzNatalie Lorenz, Thomas ProftThomas Proft, Allan Hardaker, Christina StraubChristina Straub, Julie Morgan, Audrey Tiong, Anneka AndersonAnneka Anderson, Rachel H. Webb, Julie BennettJulie Bennett, Philip E. Carter, Nicole J. Moreland<p dir="ltr">M1<sub>UK</sub> is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that M1<sub>UK</sub> is now the dominant invasive <i>emm</i>1 lineage in Aotearoa New Zealand and is genomically related to community infections, suggesting that measures that effectively prevent group A <i>Streptococcus</i> pharyngitis in children could reduce invasive disease.</p>
Funding
Manatū Hauora, Ministry of Health New Zealand (contract 370383-00)
History
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