10.26091/ESRNZ.9566477.v1
Jo-Anne E. Cavanagh
Jo-Anne E.
Cavanagh
Katherine Trought
Katherine
Trought
Caroline Mitchell
Caroline
Mitchell
Grant Northcott
Grant
Northcott
Louis A. Tremblay
Louis A.
Tremblay
Assessment of endocrine disruption and oxidative potential of bisphenol-A, triclosan, nonylphenol, diethylhexyl phthalate, galaxolide, and carbamazepine, common contaminants of municipal biosolids : Supplementary Data
Institute of Environmental Science and Research
2019
In vitro bioassays
Estrogen
Androgen
Thyroid
Redox
Aryl hydrocarbon receptor
biosolids
Soil conditioner
Feritlizer
New Zealand
Environmental Management
Environmental Monitoring
Environmental Rehabilitation (excl. Bioremediation)
2019-08-19 04:23:30
Dataset
https://research.esr.cri.nz/articles/dataset/Assessment_of_endocrine_disruption_and_oxidative_potential_of_bisphenol-A_triclosan_nonylphenol_diethylhexyl_phthalate_galaxolide_and_carbamazepine_common_contaminants_of_municipal_biosolids_Supplementary_Data/9566477
<p>The use of biosolids as a soil conditioner and fertiliser is
hindered by the limited knowledge on the risks of micro-contaminants they
contain. This study investigated the binding of six organic contaminants
commonly found in biosolids, to the estrogen (ER), androgen (AR), aryl
hydrocarbon (AhR), and transthyretin (TTR) receptors and their redox activity.
Triclosan (TCS), bisphenol-A (BPA), and technical nonylphenol (TNP) had
affinity for the TTR with relative potencies of 0.3, 0.03, and 0.076
respectively. Further, binding to TTR was the only toxicological response
observed for carbamazepine, which induced sub-maximal response and relative
potency of 0.0017. Estrogenic activity was induced by BPA, galaxolide (HHCB),
diethylhexyl phthalate (DEHP) and TNP with BPA having the strongest potency of
5.1 × 10−6 relative to estradiol. Only BPA showed androgenic activity, but it
was not quantifiable. BPA also showed anti-androgenic activity along with TCS,
HHCB, and TNP in the order of TNP > HHCB > TCS ~ BPA (relative potencies
0.126, 0.042, 0.032, 0.03). No compounds exhibited anti-estrogenic or AhR
activity or were redox-active in the dithiothreitol assay. The results highlight
the multiple modes of action through which these compounds may impact exposed
organisms, and the concentrations at which effects may occur. This allows
assessment of the likelihood of effects being observed at environmental
concentrations, and the potential contribution of these compounds.</p>